41 research outputs found

    Tolérance aux fautes dans les systèmes autonomes

    Get PDF
    Les systèmes autonomes suscitent aujourd'hui un intérêt croissant, que ce soit dans le domaine des robots d'exploration spatiale ou dans des domaines plus proches de l'homme, tels que les robots de service. Mais se pose le problème de leur sûreté de fonctionnement : peut-on avoir une confiance justifiée dans le comportement de systèmes conçus pour prendre des décisions sans intervention humaine? L'objectif de cette thèse est de proposer des concepts architecturaux capables d'améliorer la sûreté de fonctionnement des systèmes autonomes, en particulier par la conception et le développement de mécanismes de tolérance aux fautes adaptés à la fonction de planification, centrale à l'autonomie des systèmes complexes. Une évaluation des performances et de l'efficacité des mécanismes proposés est réalisée en utilisant la technique d'injection de fautes par mutation. ABSTRACT : Autonomous systems generate today a rising interest, whether in fields such as space exploration or applications nearer to man such as medical assistants, tour guides or utonomous vehicles. However, such critical applications raise the question of their dependability : can we justifiably trust systems designed to take decisions without human intervention? The objective of this thesis is to propose architectural concepts able to improve dependability in autonomous systems. In particular, it presents the design and implementation of fault tolerance mechanisms adapted to planning, an essential functionality in autonomous systems. An evaluation of the performance and the efficacy of the proposed mechanisms is realized by fault injection through source code mutatio

    Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting

    Get PDF
    Early mobilization of critically ill patients with the acute respiratory distress syndrome (ARDS) has emerged as a therapeutic strategy that improves patient outcomes, such as the duration of mechanical ventilation and muscle strength. Despite the apparent efficacy of early mobility programs, their use in clinical practice is limited outside of specialized centers and clinical trials. To evaluate the mechanisms underlying mobility therapy, we exercised acute lung injury (ALI) mice for 2 days after the instillation of lipopolysaccharides into their lungs. We found that a short duration of moderate intensity exercise in ALI mice attenuated muscle ring finger 1 (MuRF1)?mediated atrophy of the limb and respiratory muscles and improved limb muscle force generation. Exercise also limited the influx of neutrophils into the alveolar space through modulation of a coordinated systemic neutrophil chemokine response. Granulocyte colony-stimulating factor (G-CSF) concentrations were systemically reduced by exercise in ALI mice, and in vivo blockade of the G-CSF receptor recapitulated the lung exercise phenotype in ALI mice. Additionally, plasma G-CSF concentrations in humans with acute respiratory failure (ARF) undergoing early mobility therapy showed greater decrements over time compared to control ARF patients. Together, these data provide a mechanism whereby early mobility therapy attenuates muscle wasting and limits ongoing alveolar neutrophilia through modulation of systemic neutrophil chemokines in lung-injured mice and humans.Fil: Files, D. Clark. School Of Medicine; Estados UnidosFil: Liu, Chun. School Of Medicine; Estados UnidosFil: Pereyra, Andrea Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner". Universidad Nacional de la Plata. Facultad de Ciencias Médicas. Instituto de Investigaciones Bioquímicas de La Plata "Prof. Dr. Rodolfo R. Brenner"; ArgentinaFil: Wang, Zhong Min. University Wake Forest; Estados Unidos. School Of Medicine; Estados UnidosFil: Aggarwal, Neil. Johns Hopkins Asthma And Allergy Center; Estados UnidosFil: D´Alessio, Franco. Johns Hopkins Asthma And Allergy Center; Estados UnidosFil: Garibaldi, Brian T.. Johns Hopkins Asthma and Allergy Center; Estados UnidosFil: Mock, Jason R.. Johns Hopkins Asthma and Allergy Center; Estados UnidosFil: Singer, Benjamin D.. Johns Hopkins Asthma and Allergy Center; Estados UnidosFil: Feng, Xin. Wake Forest School of Medicine; Estados UnidosFil: Yammani, Raghunatha R.. Wake Forest School of Medicine; Estados UnidosFil: Zhang, Tan. Wake Forest School of Medicine; Estados UnidosFil: Lee, Amy L.. Wake Forest School of Medicine; Estados UnidosFil: Philpott, Sydney. Wake Forest School of Medicine; Estados UnidosFil: Lussier, Stephanie. Wake Forest School of Medicine; Estados UnidosFil: Purcell, Lina. Wake Forest School of Medicine; Estados UnidosFil: Chou, Jeff. Wake Forest School of Medicine; Estados UnidosFil: Seeds, Michael. Wake Forest School of Medicine; Estados UnidosFil: King, Landon S.. Johns Hopkins Asthma and Allergy Center; Estados UnidosFil: Morris, Peter E.. Wake Forest School of Medicine; Estados UnidosFil: Delbono, Osvaldo. School Of Medicine; Estados Unido

    Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting

    Get PDF
    Early mobilization of critically ill patients with the acute respiratory distress syndrome (ARDS) has emerged as a therapeutic strategy that improves patient outcomes, such as the duration of mechanical ventilation and muscle strength. Despite the apparent efficacy of early mobility programs, their use in clinical practice is limited outside of specialized centers and clinical trials. To evaluate the mechanisms underlying mobility therapy, we exercised acute lung injury (ALI) mice for 2 days after the instillation of lipopolysaccharides into their lungs. We found that a short duration of moderate intensity exercise in ALI mice attenuated muscle ring finger 1 (MuRF1)–mediated atrophy of the limb and respiratory muscles and improved limb muscle force generation. Exercise also limited the influx of neutrophils into the alveolar space through modulation of a coordinated systemic neutrophil chemokine response. Granulocyte colony-stimulating factor (G-CSF) concentrations were systemically reduced by exercise in ALI mice, and in vivo blockade of the G-CSF receptor recapitulated the lung exercise phenotype in ALI mice. Additionally, plasma G-CSF concentrations in humans with acute respiratory failure (ARF) undergoing early mobility therapy showed greater decrements over time compared to control ARF patients. Together, these data provide a mechanism whereby early mobility therapy attenuates muscle wasting and limits ongoing alveolar neutrophilia through modulation of systemic neutrophil chemokines in lung-injured mice and humans.Facultad de Ciencias Médica

    Extending our scientific reach in arboreal ecosystems for research and management

    Get PDF
    The arboreal ecosystem is vitally important to global and local biogeochemical processes, the maintenance of biodiversity in natural systems, and human health in urban environments. The ability to collect samples, observations, and data to conduct meaningful scientific research is similarly vital. The primary methods and modes of access remain limited and difficult. In an online survey, canopy researchers (n = 219) reported a range of challenges in obtaining adequate samples, including ∼10% who found it impossible to procure what they needed. Currently, these samples are collected using a combination of four primary methods: (1) sampling from the ground; (2) tree climbing; (3) constructing fixed infrastructure; and (4) using mobile aerial platforms, primarily rotorcraft drones. An important distinction between instantaneous and continuous sampling was identified, allowing more targeted engineering and development strategies. The combination of methods for sampling the arboreal ecosystem provides a range of possibilities and opportunities, particularly in the context of the rapid development of robotics and other engineering advances. In this study, we aim to identify the strategies that would provide the benefits to a broad range of scientists, arborists, and professional climbers and facilitate basic discovery and applied management. Priorities for advancing these efforts are (1) to expand participation, both geographically and professionally; (2) to define 2–3 common needs across the community; (3) to form and motivate focal teams of biologists, tree professionals, and engineers in the development of solutions to these needs; and (4) to establish multidisciplinary communication platforms to share information about innovations and opportunities for studying arboreal ecosystems

    Large expert-curated database for benchmarking document similarity detection in biomedical literature search

    Get PDF
    Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

    Tolérance aux fautes dans les systèmes autonomes

    No full text
    Les systèmes autonomes suscitent aujourd'hui un intérêt croissant, que ce soit dans le domaines des robots d'exploration spatiale ou dans des domaines plus proches de l'homme, tels que les robots de service. Mais se pose le problème de leur sûreté de fonctionnement : peut-on avoir une confiance justifiée dans le comportement de systèmes conçus pour prendre des décisions sans intervention humaine ? L'objectif de cette thèse est de proposer des concepts architecturaux capables d'améliorer la sûreté de fonctionnement des systèmes autonomes, en particulier par la conception et le développement de mécanismes de tolérance aux fautes adaptés à la fonction de planification centrale à l'autonomie des systèmes complexes. Une évaluation des performances et de l'efficacité des mécanismes proposés est réalisée en utilisant la technique d'injection de fautes par mutation.Autonomous systems generate today a rising interest, whether in fields such as space exploration or applications nearer to man such as medical assistants, tour guides or autonomous vehicles. However, such critical applications raise the question of their dependability : can we justifiably trust systems designed to take decisions without human intervention ? The objective of this thesis is to propose architectural concepts able to improve dependabiblity in autonomous systems. In particular, it presents the design and implementation of fault tolerance mechanisms adapted to planning, an essential functionality in autonomous systems. An evaluation of the performance and the efficacy of the proposed mechanisms is realized by fault injection through source code mutation.TOULOUSE-ENSEEIHT (315552331) / SudocSudocFranceF

    Functional Diversification for Software Fault Tolerance in Data Fusion: a real Application on Kalman Filters for Mobile Robot Yaw Estimation

    No full text
    International audienceIn this paper, we propose a software fault tolerant architecture for data fusion mechanisms. Our work is motivated by the difficulty to validate fusion mechanisms, either through formal approaches or testing. The proposed mechanism is based on functional diversification using the well known N-versions Programming approach, to tolerate faults in data fusion models.The general principle of our approach is to implement three diversified data fusion mechanisms, each with forcibly diversified models and independent inputs. With this diversification and a voting mechanism, our architecture provides the following fault tolerance services: software error detection, software error diagnosis and system recovery.To demonstrate the efficiency of our approach, we present a real case study consisting in estimating a mobile robot’s yaw angle using odometers and gyroscopes with a Kalman Filter. We present a fault tolerance evaluation that is based on real data acquisition by an intelligent sensor equipped vehicle (Citroen C5), this real data offline replay, and fault injection techniques.In our opinion, the main original contribution of this paper is to propose software fault tolerance mechanisms in data fusion, which are rarely considered in the literature. Indeed, we believe that these faults can have an important impact on the system’s behavior, are difficult to detect and eliminate through validation, and are prone to appear considering that empirical values (such as gains or belief mass functions) are used in data fusion
    corecore